It was unclear whether a person’s lifestyle influences the risk of developing psoriasis in the presence of varying genetic risk levels. I tried to investigate the relationship between
Data from the UK Biobank, which enrolled 500,000 people, served as the basis for the study. There were three groups of genetic risk: low, medium and high. Body mass index, smoking, physical activity, and diet constituted lifestyle scores, which were also divided into three groups: ideal, intermediate, and poor. The risk of developing psoriasis associated with each degree of lifestyle was examined within each genetic risk category and contrasted with the ideal lifestyle group with low genetic risk.
The poor lifestyle, high genetic risk group was associated with a hazard ratio of up to 4.625 (95% CI, 2.920–7.348) for psoriasis compared to the low genetic risk, perfect lifestyle group. I was. There was no relationship between a person’s lifestyle and genetic risk. The population-attributable lifestyle and genetic risk percentages were 32.2% (95% CI, 25.1% -38.6%) and 13.0% (95% CI, 3.2% -21.8%), respectively.
Independent of genetic risk, lifestyle variables predicted the likelihood of developing psoriasis and their proportional importance exceeded genetic risk.
Reference: jaad.org/article/S0190-9622(22)00604-1/fulltext
